If you’ve tried different medications without success, or experienced side effects that stop you from feeling better, you may have wondered: “Why isn’t my treatment working for me?”
Pharmacogenetic testing (PGx) can help. By looking at your DNA, it shows how your body processes medications—giving doctors clues about which drugs may work best, and which may cause problems. But one big question remains: how can I get pharmacogenetic testing on the NHS?
The answer is “yes.” it is possible, and we have had tests funded for patients this year.
You cannot usually apply directly. Your doctor (psychiatrist, GP, or specialist) needs to make the request on your behalf.
Here’s how the process works:
Talk to your doctor – explain your struggles with side effects or lack of response.
Ask about PGx testing – mention that NHS panels have approved funding for pharmacogenetic testing in cases like yours.
Doctor applies to your local ICB – applications go through the Complex Mental Health Funding Requests (CMHFR) panel.
Panel reviews the case – they decide if testing should be funded based on your treatment history.
If approved – the NHS covers the cost (e.g. £299 in one recent case) and your doctor arranges the test.
Many people feel nervous asking their doctor for something new. You might find it helpful to say:
“I’ve read about pharmacogenetic testing. Can this help explain why my medication isn’t working, or identify a suitable alternative?”
“Can I get genetic testing on the NHS to help guide my treatment?”
“If my medications keep failing, would the NHS fund a pharmacogenomic test for me?”
These questions open the conversation and give your doctor the opportunity to explain the options.
Funding decisions are not automatic. The NHS panel looks at:
Non-response – if you’ve tried several medications without success.
Side effects – if treatment causes problems that stop you from continuing.
Clinical risk – if further trial-and-error prescribing could harm your health.
If one or more of these apply, your doctor has a strong case to request PGx testing on your behalf.
It’s worth knowing the difference between NHS genetic testing and pharmacogenomic testing:
NHS genetic tests check for inherited conditions such as rare diseases and inherited cancer risks.
Pharmacogenomics is different: it focuses on how your genes affect your response to medicines.
Both rely on your DNA, but the purpose is different. PGx is about getting the right medication for you.
If you’re wondering “How can I get PGx testing on the NHS?” — the answer is: ask your doctor. While not routine everywhere, NHS funding panels have approved pharmacogenetic testing for patients with clear clinical needs.
AttoPGx can provide information packs you can share with your doctor, making it easier to start the conversation.